Name | metixene hydrochloride |
Synonyms | Methixene NSC 78194 Tremaril hydrochloride metixene hydrochloride Methixene Hydrochloride RSXZRFHNNTTWCB-UHFFFAOYSA-N 9-(1-Methyl-3-piperidylmethyl)thioxanthene hydrochloride 1-Methyl-3-(thioxanthen-9-ylmethyl)-1-piperidine hydrochloride 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine hydrochloride hydrate Piperidine, 1-methyl-3-(9H-thioxanthen-9-ylmethyl)-, hydrochloride (9CI) Piperidine, 1-methyl-3-(thioxanthen-9-ylmethyl)-, hydrochloride (6CI, 7CI, 8CI) |
CAS | 1553-34-0 |
EINECS | 2163001 |
InChI | InChI=1/C20H23NS.ClH.H2O/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20;;/h2-5,8-11,15,18H,6-7,12-14H2,1H3;1H;1H2 |
Molecular Formula | C20H23NS.ClH |
Molar Mass | 345.936 |
Melting Point | 209-210 °C |
Boling Point | 419.7°C at 760 mmHg |
Flash Point | 207.6°C |
Vapor Presure | 2.99E-07mmHg at 25°C |
Storage Condition | Room Temprature |
biological activity | Metixene hydrochloride is an anticholinergic and antiparkinsonian agent, which can effectively inhibit quinine diphenylhydroxyacetate and muscarinic receptor (muscarinic receptor) binding, IC50 and Kd values are 55 nM and 15 nM respectively. |
target | IC50: 55 nM (mAChR) Ki: 15 nM (mAChR) |